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Adolescence begins with puberty - from 8 to 14 years old, in girls, and from 9 to 15 years old, in boys. This is the phase in which not only major physical changes occur, but also psychological and even relational changes. In this phase, the "chemical messengers" - the hormones testosterone, in boys, and estrogen and progesterone, in girls -, which were inhibited in childhood, trigger the appearance of secondary sexual characteristics, giving human beings the physical traits they will have in adult life. Sometimes during adolescence, pimples appear on the face. This inflammation and obstruction of the pores of the skin, called acne, is caused by an increased production of sebum (fat) from the sebaceous glands of the skin, due to intense hormonal activity.